Scientist, Mass Spectrometry



Denver, CO, USA
Posted on Friday, June 7, 2024

Mass Spectrometry Scientist, or Senior Scientist

AOA Dx is developing the next frontier in early-stage cancer detection through its pioneering work in glycolipids and proprietary biomarker technology. Our revolutionary tumor marker ganglioside platform, GlycoLocate™, is paving the way for life-saving early cancer detection. In a first of its kind, AOA Dx is developing AKRIVIS GD™, an early-stage liquid biopsy test for ovarian cancer.

We are seeking a talented and experienced Mass Spectrometry Scientist with a PhD in chemistry, biochemistry, or a related field. In this position, you will be responsible for running, troubleshooting, and independently designing and performing high throughput lipidomics experiments on our state-of-the-art LC-MS/MS and HPLC instrument(s). This role requires a deep understanding of mass spectrometry, HPLC, large scale “omics” analysis methods, and hands-on instrumentation experience in a mass spectrometry-focused lab environment. This position is open at both the Scientist and Senior Scientist level. Role designation will be based on experience of individual candidate.


  • Independently design and execute high throughput experiments examining lipid content of serum using a tandem MS platform for either biological characterization or analytical platform development
  • Independently analyze lipidomic data to draw conclusions on either cancer biology questions or analytical platform development
  • Independently design method development experiments for analyte separation, detection and quantification using HPLC with ELSD
  • Independently plan quarterly goals, metrics and milestones and be able to track to those over time
  • Work with other scientists, research associates and technicians to plan and divide up work on a weekly basis
  • Present findings and progress to a diverse range of individuals in team meetings
  • Operate, maintain and optimize HPLC-MS instruments with precision and accuracy
  • Troubleshoot instrument issues, calibrate instrumentation and perform routine maintenance.
  • Maintain accurate records of experiments and results using an electronic lab notebook
  • Contribute to the development and optimization of analytical methods.
  • Stay current with emerging trends and advancements in mass spectrometry technology.


  • PhD in Analytical chemistry, biochemistry, biology, or chemistry or related field
  • Minimum of 4+ years of hands-on experience operating and maintaining an LC-MS system and running high throughput -omics experiments (lipidomics, metabolomics or proteomics)
  • Knowledge of biological sample preparation and extraction techniques for downstream LC-MS and HPLC analysis
  • 2+ years' experience in biotech or pharma industry is preferred
  • Proficiency in HPLC-MS operation and troubleshooting.
  • Strong analytical and problem-solving skills.
  • Excellent attention to detail and ability to maintain precise records.
  • Effective communication skills and the ability to work collaboratively in a team.

The salary range for this position is $125,000 to $145,000 per year, which factors in various geographic regions. The actual compensation and seniority level for this position will be determined based on relevant experience and qualifications.

AOA Dx offers competitive benefits, including unlimited PTO, group health, dental, and vision insurance, 100% employee sponsored life and disability benefits, monthly cell phone reimbursement, and a 401k plan with employer match.

For consideration, please apply via LinkedIn or email us with your resume referencing MASSSPEC in the subject line to

We foster an environment where all people are afforded the freedom to pursue their passions without regard to race, color, religion, national or ethnic origin, gender (including pregnancy), sexual orientation or expression, age, disability or veteran status or any other characteristics protected by law.