Mass Spectrometry Scientist
AOA
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Posted on Mar 7, 2026
Introduction
AOA Dx exists to transform women’s health. We are leading the next generation of cancer diagnostics, applying lipidomics, proteomics, and machine learning to enable earlier diagnosis of ovarian cancer for women with signs and symptoms - an area where no diagnostic tool exists today.
The Opportunity
AOA Dx is seeking an experienced Mass Spectrometry Scientist to join our Research & Development team and play a central role in advancing AKRIVIS GD™, our early-stage ovarian cancer liquid biopsy program.
This role will lead LC-MS/MS method development and high-throughput serum biomarker analysis within our multi-omics platform. The newly hired scientist will contribute directly to biomarker optimization, assay robustness, and translational readiness as we progress toward regulatory and clinical milestones.
This is not a routine instrument operator position — it is a scientifically independent, method-driven role with real influence on assay performance and development strategy.
Key Responsibilities
LC-MS Strategy & Method Development
- Independently design, develop, and optimize LC-MS/MS methods for lipid and small-molecule biomarkers
- Define analytical strategies to improve sensitivity, specificity, reproducibility, and throughput
- Operate, maintain, calibrate, and troubleshoot triple quadrupole and/or high-resolution LC-MS systems
Experimental Design & Biomarker Optimization
- Design and execute high-throughput serum biomarker experiments
- Evaluate biomarker performance across experimental conditions
- Contribute to assay refinement and analytical robustness
Data Analysis & Scientific Communication
- Analyze complex LC-MS datasets using appropriate statistical approaches
- Maintain precise documentation in electronic lab notebooks
- Present findings to internal stakeholders and contribute to scientific publications and conferences
Cross-Functional Collaboration
- Collaborate with computational biology, clinical, and regulatory teams to advance assay development
- Support milestone-driven R&D objectives
- Contribute to translational readiness and regulatory-aligned analytical practices
Qualifications
- PhD in Analytical Chemistry, Biochemistry, or related field
- (MS/BS candidates with substantial, relevant industry experience considered)
- 4+ years hands-on experience operating and maintaining LC-MS systems
- 2+ years of LC-MS method development experience
- Biotech or pharma industry experience (level varies by degree)
- Strong understanding of lipid and/or small molecule biology preferred
- Experience in biological sample preparation for downstream LC-MS/HPLC
- Strong analytical, statistical, and problem-solving skills
- Ability to translate complex data into clear insights
Why Join AOA Dx
Impact & Ownership
- Contribute to a first-in-class diagnostic platform focused on early cancer detection in women
- Play a visible role in advancing a technology designed to change clinical outcomes
Equity & Performance Alignment
- All full-time employees participate in a structured stock option program
- Equity aligned with company milestones and performance
- Bonus pool and recognition programs designed to reward impact and culture embodiment
- Employee referral program
Compensation & Benefits
- Competitive base salary
- 401(k) with employer match
- Comprehensive medical, dental, and vision coverage
- Employer-sponsored life and disability insurance
- Unlimited PTO
AOA Dx is an equal opportunity employer (EOE) and welcomes candidates from all backgrounds. We foster an environment where all people are afforded the freedom to pursue their passions without regard to race, color, religion, national or ethnic origin, gender (including pregnancy), sexual orientation or expression, age, disability or veteran status or any other characteristics protected by law.
This job is no longer accepting applications
See open jobs at AOA.See open jobs similar to "Mass Spectrometry Scientist" AlleyCorp.
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